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A prospective in silico analysis of interdisciplinary and interobserver spatial variability in post-operative target delineation of high-risk oral cavity cancers: Does physician specialty matter

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First, in vitro studies predominantly use immortalized cell lines (e.g., HepG2, L02) or primary hepatocytes under simplified lipid overload conditions, failing to recapitulate the complex in vivo microenvironment of NAFLDincluding crosstalk between hepatocytes, hepatic stellate cells, and immune cells, or systemic metabolic dysregulation