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Some of the most common benzodiazepines include: Xanax (alprazolam) Valium (diazepam) Klonopin (clonazepam) Ativan (lorazepam) Signs of Benzo Addiction Taking benzodiazepines in higher doses or more frequently than prescribed Continuing to use despite negative consequences Experiencing anxiety or panic when unable to access the medication Seeking prescriptions from multiple doctors Using benzos to cope with everyday stress or emotions Benzo Withdrawal Symptoms Increased tension and anxiety Sleep disturbances and insomnia Confusion and cognitive difficulty Tremors and sweating Nausea and weight loss Muscular pain Hallucinations Seizures a potentially serious complication requiring medical supervision Depression Because benzo withdrawal can be dangerous including a risk of life-threatening seizures it is critical to detox under medical supervision

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Recurrent episodes occur in 26-54% of cases (Teele et al., 1989

Effects and relationship of ERK1 and ERK2 in interleukin-1-induced alterations in MMP3, MMP13, type II collagen and aggrecan expression in human chondrocytes