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Introduction The field of regenerative medicine has experienced considerable advancement with the development of peptide-based therapeutics targeting tissue repair and homeostatic maintenance

In men with testosterone deficiency, HRT can enhance energy levels, muscle mass, cognitive function, and overall quality of life (20)

These interconnected processes lead to deficiencies in structural proteins essential for flagellar movement, disruption of energy supply, and dysregulation of signaling pathways, thereby elucidating the molecular basis of impaired motility in asthenozoospermia

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