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doi: 10.1111/j.1472-765X.2010.02900.x 187 JohnsonM

American College of Chest Physicians and Canadian Thoracic Society 2015 85 : N-acetylcysteine treatment for patients with moderate to severe COPD and a history of 2 or more exacerbations during the previous 2 years. Conclusions COPD is clearly associated with an excessive lung oxidant burden and the rationale for exploring antioxidant therapies in this patient population is strong