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Description

Plasma zoledronic acid concentration data was obtained from 10 patients with severe osteogenesis imperfecta (4 in the age group of 3 to 8 years and 6 in the age group of 9 to 17 years) infused with 0.05 mg/kg dose over 30 minutes

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M.ClairD

Notably, the activation of mTOR or S6K1 can lead to the phosphorylation of the insulin receptor substrate-1 (IRS-1) (4345), thereby inhibiting insulin signaling pathways (46)