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[8] Ladurner G, Kalvach P, Moessler H

doi: 10.1007/s00011-010-0214-4

These findings indicate DSIP may modulate physiological states in preparation for sleep or other systemic functions

One of the key questions at this point, as Jerne explained, was whether 'the mouse contains a small number of pre-committed cells that are the only cells that can respond to a given antigen, or the mouse contains a small number of pre-formed antibody molecules of a certain type that have to attach to the antigen as a first step toward antibody formation' (Jerne, 1966)