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84,95,137,138 The knockdown of CARS1 induces ATF4 expression through the phosphorylation of eukaryotic translation initiation factor 2 subunit alpha (EIF2S1/eIF2), leading to the activation of the transsulfuration pathway to inhibit erastin-induced ferroptosis

ACSL4 (acyl-CoA synthetase long-chain family member 4) and LPCAT3 (lysophosphatidylcholine acyltransferase 3) are essential for catalyzing the conversion of free PUFAs to PUFA-PLs [22] (Fig

MSM helps counteract this by replenishing sulfur pools needed to synthesize glutathione, supporting detoxification pathways, and reducing inflammatory signaling

Further, Constant pH Molecular Dynamics Simulation (MDS) was performed with the Desmond 61 module from Schrodinger suite