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CYP is expected to have two modes of action: it easily crosses and accumulates in biological membranes leading to stimulate the production of ROS and result in oxidative damage to essential cell components caused by oxygen-free radicals (Khanna et al

Device-measured physical activity, sedentary time, and risk of all-cause mortality: an individual participant data analysis of four prospective cohort studies

V.TanakaK.WaditeeR.OshimiS.MatsuzakiY.FukuharaM.et al (2006)

The study found that the plasma circHECW2 level in MDD patients was significantly increased and was positively correlated with depression severity and anxiety symptoms