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Their effectiveness is highest when combined with a structured nutrition plan, regular physical activity, and adequate hydration

[14] [15] Research suggests these medications may influence reward pathways, potentially reducing the hedonic response to foodparticularly high-fat and high-sugar items

Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)