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Chernyuk DP, Bolshakova AV, Vlasova OL, Bezprozvanny IB

Alfred A

In addition, the activation of the transcription factor Nrf2 in HCECs upregulated AKR1C1 under hyperosmotic conditions

Their structural simplicity, compared to antibodies, often results in weaker targeting specificity, which may lead to off-target accumulation and increased toxicity [229]