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PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

10.1016/j.cgh.2013.09.047 131 NaA

Their anti-inflammatory function not only helps regulate the immune response but also promotes cognitive function

While pharmaceutical companies are careful to run trials under optimal conditions (for example, restricting patients to those most likely to benefit, only including patients that can be treated soon after onset when necessary, and ensuring accurate dosing), not all N-acetylcysteine trials represent the optimal conditions for efficacy