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In contrast, compounds with extremely low LD 50 values (e.g., azadirachtin, celangulin, and isothiocyanates) exhibit high intrinsic potency but may be limited by formulation and application constraints

Thankamony A, Capalbo D, Marcovecchio ML, Sleigh A, Jrgensen SW, Hill NR, Mooslehner K, Yeo GSH, Bluck L, Juul A, Vaag A, Dunger DB

31 Detoxification Dysfunction The role of xenobiotic metabolizing enzymes (XMEs) in the disease etiology of PD has been under investigation by numerous researchers for the last two decades

Leppilahti M, Tammela TL, Huhtala H et al: Prevalence of symptoms related to interstitial cystitis in women: A population based study in finland