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The GPX4 pathway influences DCs survival, and ferroptotic stress may compromise T-cell activation, affecting immune tolerance (91, 96)

2 Materials and methods 2.1 APAP overdose and clinical data To demonstrate the in silico dose-dependent variability, APAP overdose clinical data were obtained from the hepatotoxic study published by Patient A: Low overdose: 6.1 g of APAP, 3.9 days since APAP intake

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Effects of the GMB on the circadian rhythm of the liver were linked to several nuclear receptors (126), some activated by cholesterol analogs and possibly BAs