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Nat Rev Immunol (2013) 13(5):32135

Currently, APAP protein adduct formation and release into the circulation is being utilized as a biomarker for APAP overdose (Roberts et al

Statistical analysis was performed using IBM SPSS version 26.0 (IBM Corporation, Chicago, United States)

Hepatocyte injury triggered by ER stress, mitochondrial dysfunction, or xenobiotics produces ROS, mitochondrial DNA, and apoptotic bodies that activate Kupffer cells (KCs) and HSCs (HSCs)