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Biology of hypoxia-inducible factor-2alpha in development and disease

Sharifi-Rad M, Anil Kumar NV, Zucca P, et al

This article explains how histamine, mast cells, circadian rhythm, melatonin, and neuroinflammation intertwine to cause early morning insomnia the dreaded 4 a.m

So the, when they have fatty, because the liver is the center of metabolism, uh, including the packaging of LDL, including if there's an inflammatory process that's happening, we know that when people have atherosclerosis, that it's not just LDL, it's tiny LDL, it's, it's the A POB being elevated