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137 Importantly, the sustained synthesis of acetyl-CoA by ACLY and ACSS2 maintains a histone acetylation profile that promotes the transcription of pro-proliferative and growth genes even under nutrient-deplete conditions, thus allowing cancer cells to more rapidly induce these tumorigenic genetic programmes when microenvironmental conditions become favourable

In particular, a meta-analysis of observational studies suggested that lowering Hcy by 34 mol/L results in an approximately 3040% reduction in vascular disease [81]

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