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Despite the limitations of the current evidence base such as small sample sizes, a lack of functional validation for identified genetic variants, and limited longitudinal data, this review opens new avenues for research

Effects of mild, moderate, and severe renal impairment as well as end-stage renal disease not yet on dialysis on lomitapide exposure have not been studied [see Dosage and Administration (2.6) and Use in Specific Populations (8.6)]