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This novel small molecule has been explored in exercise mimetic research, with preclinical studies investigating its effects on mitochondrial biogenesis, endurance capacity, and metabolic gene expression

Liguori I, Russo G, Curcio F, et al

Proc Natl Acad Sci USA 2016;113:E496675

12 Cellular swelling, karyolysis, karyorrhexis, vacuolization, inflammation and release of cellular contents (alanine aminotransferase, ALT) are key processes of hepatocyte necrosis and related death in humans, as shown by the biochemical evidence of severe elevations in aminotransferases, especially ALT