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However, the regulatory framework for drug development relies heavily on animal toxicology precisely because it does provide meaningful safety signals

In hypoxic tumor microenvironments, hypoxia inducible factor 1 subunit alpha (HIF1A, also known as HIF1) represses DLAT expression and confers resistance to cuproptosis 176 , supporting the existence of a HIF1A-DLAT-GSH regulatory axis

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J Proteome Res 18(4):15131531 Stein S et al (2017) Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease