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The lateral root polysaccharides of Aconitum carmichaelii (RFP) had the cytotoxicity effects on hydrogen peroxide-induced injury and prohibited apoptosis in vitro, by contrast, RFP attenuated cisplatin-induced acute kidney injury in vivo through inhibition of ferroptosis with the increased levels of GSH and GPX4, the decreased levels of MDA and 4-hydroxynonenal as well as the reduced lipid peroxidation (Tian et al., 2022)

An in-depth investigation of these mechanisms will not only help to elucidate the complex regulatory network of NRF2 in cellular protective mechanisms but also provide new targets and strategies for the treatment of related diseases

This ensures the peel penetrates evenly

27 The GHR also cross-talks and/or forms complexes with several other growth factor and hormone receptors (Fig