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Over time, this nerve damage can become more severe and even lead to coordination problems and difficulty walking

Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

Key considerations for individuals with transcobalamin mutations include: Regular monitoring of vitamin B12 status Potential need for alternative forms of vitamin B12 supplementation Genetic counseling for family members Genetic Testing Recommendations Genetic testing is a good idea for those thinking about vitamin B12 supplements