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2018), and because it is expressed in the area postrema of the medulla, along gastric enteric and vagal nerves, and on cutaneous receptors in the dermis and epidermis (Tissue expression of TRPV1 - Summary - The Human Protein Atlas n.d), researchers postulate that repetitive TRPV1 activation may cause vomiting from overexcitation, or relief from the vomiting under acute activation of the hot shower

Some people need higher doses if they have absorption issues or severe deficiencies

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