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A substantial complication or comorbidity was defined as a condition that, because of its presence with a specific principal diagnosis, would cause an increase in the length-of-stay by at least 1 day in at least 75 percent of the patients

The structural integrity of the mucosal linings in the gut and respiratory tractwhere mast cells are highly concentratedis also compromised when sulfur levels are low, making these tissues even more reactive to environmental triggers

Conversely, it increases genes associated with vascular injury or angiogenesis, such as platelet glycoproteins GP5 and GP9, suggesting that 16-OHE may induce inflammation through noncytokine pathways, although the precise mechanism remains unclear [41]