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234 The nonsteroidal anti-inflammatory drug diclofenac can significantly reduce the protein expression level of NF-B p65 and the phosphorylation level of IB-, effectively protecting the structure and function of the intestinal barrier by suppressing the iNOS/NF-B pathway and activating the expression of HO-1

Comment: A commenter mentioned our proposed regulation text edits and noted that the changes discussed in the preamble did not align with what was included in the regulation text at the end of the proposed rule and suggested that there may have been an inadvertent drafting error