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Further analysis revealed that GRF-6 interacts with the vasoactive intestinal peptide receptor (VPAC1-R), suggesting this receptor is responsible for the diarrheal effects

Researchers running dose-response work should reference the COA molar values directly when calculating administered nmol/kg

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Increased levels of these metabolites are associated with increased expression of VCAM-1, and increased leukocyte adherence to vascular endothelium in mice, suggesting that an inflammation-dependent mechanism may underly the association of these metabolites with the development of major CV adverse events (Ferrell et al, 2024)