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Huang D, Wang Y, Thompson JW,Yin T, Alexander PB,Qin D,Mudgal P, Wu H,Liang Y

A review of global health data underscores the gravity of the situation: cardiovascular diseases have become the leading cause of global mortality, accounting for nearly 18 million deaths annually (Roth et al., 2020)

As a scavenger of toxic free radicals, GSNO is 100-fold more potent in neutralizing ROS than GSH and is further metabolized by an evolutionary conserved enzyme S-nitrosoglutathione reductase (GSNOR) at the expense of NADH to generate GSSG and ammonia (Figure 3)