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In the context of aging, peptides are particularly valuable because they address many hallmarks of aging, such as reduced collagen and elastin synthesis, inflammation, oxidative stress, and slower cell turnover

Toxins (Basel), 10(11), 474

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Findings from preclinical studies, for example, antinociceptive activity to some extent corroborated with data from self-report studies of which among the reasons for kratom use is to manage pain, further supported by the recent randomized controlled study in humans ( FIGURE 1 Here, we highlight physiological interactions of kratom alkaloids focusing on interactions with enzymes, receptors, and cellular barriers