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Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing

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Cost considerations Pharmaceutical semaglutide (Wegovy): $1,300-1,500/month without insurance Insurance may cover (varies) Patient assistance programs available Research semaglutide: $150-300/month No insurance No patient assistance User assumes risk Research cagrilintide: $200-400/month Not prescription available yet Higher cost due to limited availability Total CagriSema combination cost (research chemicals): $350-700/month Both peptides at full dose Significant investment Compare to bariatric surgery ($15,000-25,000 upfront) Budget planning: Year 1 (titration + maintenance): $4,200-8,400 Ongoing maintenance: $350-700/month Consider reducing to maintenance doses May need 12-24+ months total Use our peptide cost calculator to budget protocols