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C., Son W

Briefly, 6His-Flag-Sororin or Sororin PAR mutants were incubated with Ni-NTA agarose for 1 h at 4 C

Various clinical studies have demonstrated the therapeutic efficacy of the ophthalmic formulation of netarsudil : (i) 0.02% netarsudil was reported to increase the mean diurnal outflow by 0.22% after 7 days of treatment [276], (ii) once daily dosing of netarsudil 0.02% reduced the mean diurnal IOP by 5.76.8 mmHg [278], (iii) noninferior clinical efficacy in reducing IOP, relative to timolol , in two separate phase 3 trials [279], and (iv) long-term efficacy in consistently lowering IOP throughout a 12-month study period [280]

Abstract Gastric cancer (GC) remains a significant global health burden, characterized by high mortality rates, often due to late-stage diagnosis, resistance to conventional therapies, and metastatic dissemination