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Why It Matters in ME/CFS and Fibromyalgia: Directly addresses mitochondrial dysfunction, a hallmark of both conditions

4.11 Total proteomics and phosphoproteomics analysis by liquid chromatography combined with tandem mass spectrometry Be(2)-C cells were cultured in triplicates in 10 cm dishes and treated the following day either with MitoQ IC50, DPI IC50, Vin IC50, (M+D)/2, (M+D+V)/3, or vehicle for 24 h and washed once with PBS

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This is particularly relevant for MASH and HCC development as the synthesis of BA through the classic pathway controlled by CYP7A1 is repressed by endoplasmic reticulum (ER) stress