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Biochem Pharmacol 119:7684 Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians

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Absolute deficiency or malfunction of CBS disrupts this pathway, leading to elevated blood and urine levels of homocysteine and methionine, and reduced cysteine levels (18)