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However, functional downregulation and/or desensitization of MOR has also been observed in the spinal dorsal horn, particularly in laminae I and II, in nerve-injury neuropathy [101,130] and diabetic neuropathy [131,132], although with no significant decrease in expression [78,130,131,132]

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Under unstressed conditions, MANF and glucose-regulated protein 78 (GRP78) are expressed at low levels