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Clearly, the reference limit or cutoff applied to designate inadequate vitamin B12 status may vary, leading to differences in the literature on reports for the prevalence estimates for vitamin B12 deficiency

Importantly, patients were already on glucocorticoid treatment before blood collection for this study, which may explain why higher levels of mRNA were not found for some genes, such as CCL2 , CXCL9 , IL6 , IL17A , CCL1 and TNF in MOD and/or SEV patients compared to CTRL at endpoints Z and A ( Figure S2 and Figure 3 )

Can start with 5mg twice weekly

However, folic acid cannot fix the damage to the nervous system caused by low B12, which can lead to permanent nerve damage if the B12 deficiency isn't found and treated