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Covalent/irreversible inhibitors target the redox/catalytic apparatus of TGR with almost no recognition elements that give affinity and selectivity for TGR over off-targets and the cellular redox apparatus resulting in undesirable cross-reactions and low specificity in vivo 25

Silica nanoparticles coated with polydopamine exhibit pH-sensitive mucus penetration, with diffusion rates approximately three times higher at pH 5.6 close to their isoelectric point than at more acidic (pH 3) or neutral (pH 7) conditions 184,185

ROS have crucial roles in normal physiological processes, such as through redox regulation of protein phosphorylation, ion channels, and transcription factors

A comprehensive understanding of the risks and rewards of COVID-19 vaccination, especially during pregnancy, remains essential