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Hydrochlorothiazide has been shown to increase the urinary excretion of magnesium and potassium

7,18 Hepatic effects , including transient elevations in liver enzymes in clinical studies and, at excessively high doses in nonclinical studies, evidence of acute hepatic injury

Paradoxically, smt15-1 single mutant has daughter cells that are smaller than those of the wild-type, indicating that SMT15 has a negative regulatory role in controlling size-dependent cell division