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Depleted glutathione by NAPQI leads to increased H 2 O 2 release that oxidizes thioredoxin and induces the disassociation of thioredoxin from apoptosis signalling-regulating kinase 1 (ASK-1), triggering self-activation of ASK-1, which phosphorylates mitogen-activated protein kinase kinase 4/7 and activates c-Jun N-terminal kinase (JNK) (Hanawa et al., 2008

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Additionally, integration of gene expression data has identified 269 differentially expressed programmed cell death-related genes (DPGs) in endometriosis, with 17 showing causal associations and three (TNFSF12, AP3M1, PDK2) emerging as potential diagnostic biomarkers ( Epigenetic dysregulation plays a central role, involving DNA methylation, histone modifications, and non-coding RNAs