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rescued with luciferase control, WT or Neh4/5mut NRF2

However, other pathophysiological modifications within melanoma cells may contribute to therapy resistance [4, 5], demanding for large-scale computational models to simulate the complex physiology of a tumour in an integrated manner and comprehensively foster the identification of alternative therapeutic vulnerabilities applying high throughput in silico approaches [6, 7]

doi: 10.1038/nature14344 55 HuWZhangCWuRSunYLevineAFengZ