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Wang Y, Kuca K, You L, Nepovimova E, Heger Z, Valko M, Adam V, Wu Q, Jomova K (2024) The role of cellular senescence in neurodegenerative diseases

Mouse experiments have shown that knockdown of Bnc1 leads to downregulation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)/silent mating type information regulation 2 homolog 1 (SIRT1)/Forkhead Box O3 (FOXO3) signaling, which in turn leads to mitochondrial dysfunction, decreased mitochondrial membrane potential, elevated ROS production, and increased expression of cytochrome c (Cyt-c), resulting in spermatogonial apoptosis and the failure of sperm production [88]

Chiang CL, Chan KSK, Li H, Ng WT, Chow JCH, Choi HCW, et al

Neurosignals 14(12):7182 Wang LS, Zhou J, Shao XM, Tang XC (2002) Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxiaischemia