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Importantly, this work also underscores the flexibility and efficiency of incorporating ncAAs for mechanistic investigations, further demonstrating the utility of this toolkit in elucidating the role of active residues within proteins

Prbstel AK, Zhou X, Baumann R, Wischnewski S, Kutza M, Rojas OL, et al

Specifically, mycotoxins have been shown to: Suppress cytokine production, altering immune signaling Induce apoptosis (programmed cell death) in immune cells Disrupt the intestinal epithelial barrier, contributing to leaky gut Impair macrophage and dendritic cell function Alter the balance between inflammatory and regulatory immune pathways (Th1/Th2/Th17/Treg axis) Aspergillus fumigatus produces gliotoxin, which actively suppresses the immune systems ability to fight off fungal infection by inhibiting phagocytosis