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LCMS (ES, m/z) calculated for C 15 H 18 N 5 + [(M + H) + ] 268.2, observed 268.1 Synthesis of 4-(1-cyclopropyl-[1,2,4]triazolo[4,3- a ]quinolin-7-yl)piperazin-1-ium 2,2,2-trifluoroacetate (6c) a Intermediate 5c was treated with TFA according to general procedure 6a-6d

Meanwhile, myeloid-cell specific GPX4 haploinsufficient mice presented with SLE-like manifestations such as spontaneous skin lesions and systemic damage, further validating that ferroptosis of neutrophils serves a critical role in the pathogenies of SLE

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The synthesis of GCL, along with other targets involved in the antioxidant response, is under the control of the transcription factor, Nrf2 (Baird and Dinkova-Kostova 2011)