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MDSCs not only exert potent immunosuppressive effects that hinder the success of immune checkpoint inhibitors (ICIs) and adaptive cellular therapies, but they also promote tumor advancement through non-immunological pathways, including promoting angiogenesis, driving epithelial-mesenchymal transition (EMT), and contributing to the establishment of pre-metastatic environments

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However, while antioxidants are generally considered safe, they can have side effects

Upper respiratory : nasal symptoms (e.g., sneezing, rhinorrhea, nasal pruritus, and/or nasal congestion), throat-clearing (itchy throat), cough not related to bronchospasm