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More help Evidence Assessment Addressess the biological plausibility, empirical support, and quantitative understanding from each KER in an AOP

297 However, overexpression of PINK1 inhibit the mtDNA-cGAS-STING pathway, so impaired mitophagy boosts inflammatory responses by promoting mtDNA DAMPs in aging

In contrast to their protein-bound counterpart, FAAs can interact with specific receptors present on a wide variety of cells in various parts of the body, including the intestines, where they can activate specific intracellular pathways and confer physiological effects (34, 48)