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[12] Cyanide binds preferentially to hydroxocobalamin over cytochrome oxidase (a3) within the mitochondria and makes hydroxocobalamin an effective antidote

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For example, it has been demonstrated that mHtt inhibits the delivery of the mitophagy receptor to autophagosomes, while simultaneously blocking autophagosome formation, disrupting mitophagy initiation, and affecting autophagosome translocation to lysosomes (Wong and Holzbaur, 2014)