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A recent systematic assessment using mitochondrial PCR array profiling identified 16 genes that were differentially expressed in the dorsolateral prefrontal cortex of post-mortem brains from depressed patients compared to control subjects (Wang and Dwivedi, 2017)

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Their resistance has been linked to their capacity to reduce ROS levels through the accumulation of intracellular antioxidants like glutathione and the induction of GCL, as demonstrated in breast and liver TICs [18,19,20]