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doi: 10.1002/bjs.4141 25

Doering, Faculty of Health Sciences, Department of Pathology and Molecular Medicine, McMaster University, HSC 1R1, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada e-mail: [email protected] This article was submitted to the journal Frontiers in Cellular Neuroscience

we observed a strong growth defect and massive cell death in the LHON-edited cells, but not in the SILENT-edited cells (population doublings per day: LHON 0.64 0.11, SILENT 0.52 0.07