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Beyond the binary exposure definition, we observed exposure-intensity patterns

Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives

Nobiletin and tangeretin belong to the group of polymethoxyflavonoids, found in the peel extract of Citrus depressa (Jang et al., 2013)

Consistent with this, use of a reducing source such as -mercaptoethanol allows reversal of xCT-KO phenotype, as it has been reported couple decades ago by Bannai's group ( in vivo can explain the discrepancy with in vitro phenotype