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Geriatric Use: An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients

The factors which are to be considered for dose estimation by transdermal route are discussed in the literature and are in general as enumerated in table 1 Table 1: Factors for consideration for Transdermal Dose Calculation Thus, dose calculation requires thorough consideration of all above factors

The injectable route ensures adequate B12 delivery regardless of gut function

Protocols commonly use subcutaneous injection in a loading-then-maintenance pattern over 46 week blocks, but there is no FDA-approved product or official dosing