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The transmembrane rather than paracellular transport of lipophilic compounds was supported by the demonstration of an inverse association between lipid/water partition coefficient and increased transport rate following calcium chelation, i.e., disrupting intercellular junctions increased the transport of hydrophilic but not of lipophilic small organic molecules [31]

This mechanism results in a chronic upregulation of pro-inflammatory cytokines (i.e., TNF- and IL-6), which are known to exert deleterious effects on the insulin signaling pathway in adipocytes, hepatocytes, and myocytes (80)

Certain groups may need to take a B12 supplement for life

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