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doi: 10.1016/j.berh.2018.10.007 14 ChenDShenJZhaoWWangTHanLHamiltonJLet al

It should be noted, however, that high AR activity may not be universally sufficient to confer sensitivity of prostate cancer to SPA, as DU145 cells transduced to express high AR remain resistant to growth inhibition by SPA, even with high AR overexpression (34)