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This may result in impaired transcription of mRNA and post-translational modification of mitochondrial proteins, including oxidative phosphorylation enzymes and proteins involved in antioxidant defense, ultimately resulting in both ROS generation and compromised ATP production [10]

The major clinical manifestations of porphyrias are neurologic , usually presenting as acute attacks, or cutaneous , resulting from phototoxicity

Additionally, research often fails to distinguish between acute and chronic exposure, limiting our ability to predict long-term outcomes

To view a copy of this licence, visit About this article Cite this article Liu, J., Zhao, L., Xie, J